ODCs

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2 OMIM references -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 10

2 OMIM references -
1 associated gene
11 signs/symptoms

Hereditary thrombophilia due to congenital protein S deficiency

Hereditary thrombophilia due to congenital protein C deficiency


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PROS1	(0.63)	PROC

Citations in the biomedical literature:

Hereditary thrombophilia due to congenital protein S deficiency		Hereditary thrombophilia due to congenital protein C deficiency
	Synonym(s): (no synonyms)		Synonym(s): - Hereditary thrombophilia due to PC deficiency

	Classification (Orphanet): (no data available)		Classification (Orphanet): - Rare bone disease - Rare genetic disease - Rare hematologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal recessive

	External references: 2 OMIM references - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Abnormal pigmentary skin changes / skin pigmentation anomalies - Cerebral vascular anomalies - Chronic skin infection / ulcerations / ulcers / cancrum - Gangrena / necrosis - Pulmonary thromboembolism - Purpura / petichiae - Skin hypoplasia / aplasia / atrophy - Thin skin - Varices / varicous veins / venous insufficiency - Venous thrombosis / phlebitis / thrombophlebitis

Hereditary thrombophilia due to congenital protein S deficiency		Hereditary thrombophilia due to congenital protein C deficiency
	Very frequent - Autosomal dominant inheritance Frequent - Anomalies of skin, subcutaneous tissue and mucosae - Retinopathy Occasional - Arterial embolism / thrombosis		Very frequent - Autosomal recessive inheritance